Experiment Pinpoints Potential Way to Halt Severe Gum Disease

MicroscopePeriodontitis is the clinical term for severe gum disease which affects almost 50% of the adult population in America. This gum tissue inflammation, combined with periodontal pockets, can lead to tooth and jawbone density loss. There are many studies that point to periodontitis have a systemic impact on overall health, as well. Farmington Hills dentist, Aziza Askari, explains a new study that focuses on halting the development of periodontitis even after it has already begun.

Receptors to Blame for Gum Disease Inflammation

Published in the Journal of Immunology, the study was led by a postdoctoral researcher in the Department of Microbiology in Penn’s School of Dental Medicine by the name of Toshiharu Abe. The senior author on the paper was professor George Hajishengallis, who employs Abe in his lab at the university. Other senior authors included an impressive group of researchers that have previously studied bacterium responsible for most severe gum disease cases. The bacteria that cause periodontitis have been compared to “hijackers” of white blood cell receptors. This triggers inflammation and a break down of the immune system, leading to periodontitis.

Research Pinpoints Periodontitis Source

Abe’s experiment focused on this receptor by using mice as models.  Mice injected with different types of molecules that activated various receptors proved that periodontitis development and/or progression could be stopped. When two particular molecules were activated together, gum disease issues were triggered. This finding suggested a sort of crosstalk between molecules that ramps up the inflammatory response. The hypothesis is that blocking one of these receptors could halt the gum inflammation all together.

Gum Disease Help in Farmington Hills

Research continues to try and help better serve dental patients with various degrees of gum disease. For now, gum disease can be treated in a variety of ways, and stopped before it starts with diligent oral hygiene and regular dental appointments. To schedule a consultation with Dr. Askari, contact Comfort Dental Spa by calling our Farmington Hills dentist office at (248) 474-6434. We are happy to serve patients in Farmington Hills, MI, the 48335 zip code, and surrounding neighborhoods.